Company Directory

Startups

Discover the companies building Louisville’s innovation economy.

96

Active Startups

17

Sectors

73

Exits

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96 startups found

El Toro

IP-targeting digital advertising platform serving ads to specific households.

Est. 2013Website

Forecastr

Financial modeling and forecasting platform for startups.

Virtual Peaker

Distributed energy resource management for utilities.

CleanTechGrowth

Repatient

Digital-first patient billing and payment platform offering flexible 0% interest payment plans for out-of-pocket medical expenses.

Resound

AI-powered podcast editing platform that automates post-production by detecting filler sounds, silences, and background noise.

MediaSeed

STEM Wizard

Science fair and STEM competition management software.

EdTechSeed

Sensegrass

AI-powered soil and crop health monitoring for agriculture.

AgTechSeed

Xena Intelligence

Amazon marketplace analytics and optimization for sellers.

Handle Global

Healthcare asset management and equipment lifecycle platform.

Liberate Medical

Medical devices for ventilator liberation and respiratory care.

MEMStim

Neurostimulation medical devices for chronic pain treatment.

NormaLyte

Medical-grade oral rehydration solutions and electrolyte supplements.

AdaptiveEndo

Innovative endoscopic surgical devices and medical instruments.

Advantum Health

Revenue cycle management and medical billing services.

HealthcareEstablished

Breath Diagnostics

Non-invasive breath analysis diagnostics for disease detection.

US WorldMeds

Specialty pharmaceutical company focused on rare and niche diseases.

Life SciencesEstablished

CreoSalus

Chemical manufacturing and custom synthesis for pharmaceutical companies.

Life SciencesEstablished

Advanced Energy Materials

Advanced materials for energy storage and battery technology.

Artemis Electronics

Custom electronics design and embedded systems development.

iKeyless

Aftermarket automotive key and remote replacement e-commerce platform.

Bourbon Barrel Foods

Artisan food products aged in bourbon barrels, including soy sauce and seasonings.

Food & BeverageEstablished

FreshFry

Sustainable frying oil filtration pods that extend oil life and reduce waste.

Horse Racing Nation

Digital media platform covering thoroughbred horse racing news and data.

MediaEstablished

MedCity News

Healthcare and life sciences industry news and events media company.

MediaEstablished

Academic Platforms

Online certified nursing assistant training and education platform.

EdTechEstablished

FindCRA

Community Reinvestment Act compliance and investment marketplace.

Lokator Pitching Academy

Data-driven baseball pitching training and analytics platform.

Misc. Goods Co.

Design-forward lifestyle brand selling playing cards, leather goods, and fragrances.

Cognision

Brain-computer interface diagnostics by NeuroNetrix for cognitive assessment.

My Rehab Pro

Physical therapy exercise platform with video-guided rehab programs.

Pronia Medical Systems

Predictive analytics for surgical quality outcomes and patient safety.

Avante Medical Surgical

Refurbished medical equipment and surgical instruments marketplace.

E-CommerceEstablished

Global Aviation Navigator

Aviation marketplace for aircraft sales, parts, and charter services.

E-CommerceEstablished

NX PharmaGen

Pharmacogenomics testing for personalized medication management.

The CMOOR Group

Security training and continuing education platform.

EdTechEstablished

Magnt

AI-powered branding platform that generates logos, brand guidelines, marketing assets, and websites for startups and small businesses.

Revoyant

AI software marketplace helping businesses discover, compare, and evaluate over 1,000 AI tools with curated reviews and product info.

Swell

Telehealth therapy app making mental wellness accessible for military families, first responders, and law enforcement.

MoneyPath

Growth marketing firm specializing in webinar-driven campaigns for sales and marketing alignment.

MarketingEstablished

ION Water

Platform helping housing developers slash water costs through smart water management.

Interapt

IT consulting and workforce development firm creating tech careers through paid apprenticeships.

Software & TechEstablished

RAAPID

AI-driven risk adjustment and NLP-powered healthcare analytics platform.

HealthcareEstablished

V-Soft Consulting

IT staffing, digital transformation, and technology solutions company with 700+ global employees.

Software & TechEstablished
Est. 1997Website

PACT Health

Healthcare venture by the co-founder of Renew Recovery (acquired by Brightview Health).

Enhale Medical

Minimally-invasive neuromodulation technology for obstructive sleep apnea treatment.

MRI Analytics

Analytics platform for operations, product development, and sales optimization.

SafetyVue

AI-powered and VR training platform revolutionizing construction workplace safety.

Est. 2024Website

Soaring Titan

AI agent integration platform elevating businesses through artificial intelligence.

Citation Labs

Enterprise link-building agency with custom tools for large-scale marketing.

MarketingEstablished

Due Gooder

AI-driven student productivity platform for managing assignments and due dates.

EdTechSeed

Lockbox AI

Automated payment posting and reconciliation platform for healthcare revenue cycle management.

HealthcareEstablished
Est. 2017Website

MaybeItsFate

Member-owned cooperative and social club in Louisville.

Est. 2024Website

Action Intel

Data analytics and AI platform for inland waterway and barge logistics, offering freight forecasts, fleet tracking, and operational intelligence.

Untitled

AI-powered audience intelligence and data activation platform for performance marketers, offering visitor identification, audience generation, and campaign activation across CTV, direct mail, and paid media.

Software & TechEstablished
Est. 2018Website

Loudega

AI-powered unattended retail company that designs, deploys, and operates compact 24/7 retail locations as everyday amenities for employers, campuses, and residential communities in Louisville.

E-CommercePre-Seed
Est. 2025Website

Essential Innovations

Technology platform helping employers and nonprofits unlock tax and training credits to meet workforce needs for essential workers.

SUSH

Designs and manufactures reusable, microwave-activated thermal warmers for pain relief and comfort. Sustainable alternative to disposable heat packs.

Synchrony Health

Pharmacy, rehabilitation, and lab services for senior housing and skilled nursing facilities.

HealthcareEstablished

BFW Inc

Designs and manufactures surgical illumination headlights and video imaging systems for medical professionals.

HealthcareEstablished

1109 Bravo

Creator of the NeuroPak, a patented wearable neuromuscular training system originally developed for U.S. Special Operations.

EZ-Chow

Online ordering and self-service kiosk platform helping restaurants increase takeout and delivery revenue.

Kare Mobile

Mobile dental practice deploying compact mobile dental units to bring oral healthcare to underserved communities.

DiningTek

All-in-one restaurant management platform offering online ordering, marketing automation, and branded apps for independent restaurants.

PrepSharp

SaaS platform for test-prep tutors providing digital tools including practice tests and grading for the ACT and SAT.

EdTechSeed

HelloSpoke

Cloud communications company specializing in automated answering and call escalation services for property management companies.

Software & TechEstablished

NX Prenatal

Molecular diagnostics company developing non-invasive blood tests for early detection of adverse pregnancy outcomes.

LockUpLead

Lead-neutralizing products that chemically convert toxic lead paint dust to non-hazardous waste for safer handling in homes and schools.

Let's Start Coding

Educational coding kits and teacher training programs that help kids and educators learn to code with hands-on electronics.

EdTechSeed

Lenderfit

Cloud-based loan origination software helping small business lenders digitize and streamline the lending process.

IGear

Manufacturing productivity software for process control, visual analysis, and team communication in industrial settings.

Software & TechEstablished

Nauga Needles

Nanotechnology company manufacturing silver-gallium nanoneedle probes used as nano-force and nano-bio sensors in research and diagnostics.

Est. 2007Website

PC3 Health

Provider-owned utilization and case management services company helping hospitals decrease observation and claim denial rates and improve financial performance. Invested $2.5M expanding Louisville operations.

Est. 2018Website

Nirvanta Health

Doctor-formulated, plant-based health and wellness brand specializing in skin recovery and discomfort relief products.

Louisville Success Stories

Acquisitions & IPOs

Louisville has a track record of building companies that reach major milestones. These companies were acquired or went public, proving the strength of the local ecosystem.

3DR Laboratories

Medical imaging and 3D reconstruction technology for healthcare.

HealthcareAcquired

Apellis Pharmaceuticals

Biopharmaceutical company developing complement immunotherapies.

Life SciencesIPO

Appriss Insights

Data analytics and risk-assessment solutions for government and healthcare. Acquired by Equifax.

Data & AnalyticsAcquired

Backupify

Cloud-to-cloud backup solutions for SaaS data protection.

Software & TechAcquired

Cartainers

Designs and manufactures specialized storage, display, and transportation containers for high-value collectible cars. Acquired in 2024.

ProductsAcquired

Capture Higher Ed

Behavioral intelligence and predictive analytics for higher education enrollment.

EdTechAcquired

Charah Solutions

Environmental and maintenance services for the power generation industry.

CleanTechIPO

Clipper Data

Commodity flow data and analytics for energy markets.

Data & AnalyticsAcquired

Clover Learning

Online diagnostic imaging education platform offering video lessons, exam prep, and continuing education for healthcare professionals. Acquired by Ascend Learning.

EdTechAcquired

Cuddle Clones

Custom plush replicas of pets, powered by e-commerce.

E-CommerceAcquired

Genscape

Real-time data and analytics for energy and commodity markets.

Data & AnalyticsAcquired

High Speed Access

Early broadband internet service provider.

Software & TechIPO

Indatus

Cloud communications and data solutions platform. Acquired by RealPage.

Software & TechAcquired

Over

Mobile design app for adding text and graphics to photos. Acquired by GoDaddy.

Software & TechAcquired

Payment Alliance International

ATM management and electronic payment solutions.

FinTechAcquired

PetFirst

Pet health insurance provider for dogs and cats.

InsurTechAcquired

Podchaser

Comprehensive podcast database and discovery platform.

MediaAcquired

Rabbit Hole Distillery

Craft bourbon distillery with innovative aging and blending techniques.

Food & BeverageAcquired

Sierra Interactive

Real estate marketing and lead generation platform.

Software & TechAcquired

SkuVault

Cloud-based warehouse management and inventory control system.

Software & TechAcquired

The Learning House

Online program management for colleges and universities.

EdTechAcquired

ZirMed

Revenue cycle management platform for healthcare. Now Waystar.

HealthcareAcquired

Venminder

Third-party risk management and vendor oversight platform. Acquired by Ncontracts (HG Capital).

Software & TechAcquired

Glennis Solutions

Senior living operations and financial management software. Acquired by Atria Senior Living.

Software & TechAcquired

PharmaCord

Patient support services and hub solutions for specialty pharma. Merged with Mercalis to form Valeris.

HealthcareMerged

RxLightning

Specialty pharmacy enrollment and prescription management platform. Acquired by CoverMyMeds (McKesson).

HealthcareAcquired

SentryHealth

Employer-based chronic disease management and health coaching. Formerly Edumedics. Acquired by First Stop Health.

HealthcareAcquired

eBlu Solutions

Benefits administration and enrollment technology platform. Acquired by Knipper Health (Frazier Healthcare Partners).

HealthcareAcquired

Networld Media Group

B2B media covering self-service technology, kiosks, and digital signage. Acquired by Connect Media.

MediaAcquired

Optical Dynamics

Nanotechnology-based UV lens curing systems for optical manufacturing. Acquired by Antevorta Capital Partners.

NanotechnologyAcquired

Advanced Cancer Therapeutics

Novel cancer treatment development and therapeutic research.

Life SciencesAcquired

Shaip

AI training data platform enabling on-demand scaling for machine learning initiatives. Acquired by Ubiquity.

Data & AnalyticsAcquired

Codigo

Digital signage and kiosk software platform for financial institutions. Acquired by Spectrio.

FinTechAcquired

iPay Technologies

Electronic bill payment platform for financial institutions. Acquired by Jack Henry & Associates for $300M+.

FinTechAcquired

RxCrossroads

Specialty pharmacy services provider offering hub, reimbursement, and 3PL services for pharma and biotech. Acquired by McKesson for $735M.

HealthcareAcquired

MedAssist

Revenue cycle management and eligibility services for the healthcare industry. Acquired by Firstsource Solutions for $330M.

HealthcareAcquired

Smoothstone IP Communications

Cloud-based enterprise VoIP and unified communications provider. Acquired by West Corporation for ~$120M.

Software & TechAcquired
Est. 2000

RowdMap

Healthcare analytics platform helping health plans identify and reduce low-value care. Acquired by Cotiviti Holdings for $70M.

HealthcareAcquired

Telapoint

Browser-based fuel inventory management and supply chain software for petroleum distributors. Acquired by WEX Inc for ~$40M.

Software & TechAcquired

StoneStreet One

Developer of Bluetopia Bluetooth protocol stack software for chipmakers and embedded devices. Acquired by Qualcomm.

Software & TechAcquired
Est. 1999

TechRepublic

IT professional media and resource website. Acquired by CNET Networks for $23M.

MediaAcquired
Est. 1997

Iron Triangle Payment Systems

Merchant payment processing company that grew to become the 6th largest US merchant processor. Acquired and rebranded into Worldpay.

FinTechAcquired

Service Net

Extended warranty underwriting and administration for major consumer product brands. Acquired by AIG.

InsurTechAcquired
Est. 1996

Onovative

Automated marketing and communication platform for community banks and credit unions. Acquired by Main Street Inc.

FinTechAcquired

Lucina Analytics

Data-driven SaaS platform delivering maternal health analytics to identify at-risk pregnancies. Acquired by Unified Women's Healthcare.

HealthcareAcquired

MedVenture Technology

Contract manufacturer of minimally invasive surgical devices and catheter-based medical devices. Acquired by Freudenberg Medical.

HealthcareAcquired

Chapman Kelly

Dependent eligibility and claims audit services for large self-insured employers. Acquired by HMS Holdings for ~$13M.

HealthcareAcquired

LABSCO

Distributor of laboratory supplies and diagnostics products to healthcare providers. Acquired by McKesson.

HealthcareAcquired

WhiteBox Learning

SaaS-based STEM education platform offering virtual and hands-on learning for grades 6-12. Acquired by Flinn Scientific.

EdTechAcquired

VoicePad

Real estate mobile search and listing technology with caller tracking for brokerages. Acquired by Elm Street Technology.

Software & TechAcquired

CIAgent

Environmental protection products for hydrocarbon spill cleanup using proprietary polymer technology. Acquired by Justrite Safety Group.

CleanTechAcquired
Est. 2000

Deyta

Clinical quality measurement and patient satisfaction analytics for home health and hospice providers. Acquired by HEALTHCAREfirst.

HealthcareAcquired

Splash Analytics

Advanced marketing analytics and predictive modeling firm specializing in data visualization. Acquired by OneMagnify.

Data & AnalyticsAcquired

Motorcycle Superstore

One of the largest online retailers of motorcycle gear, parts, and accessories. Acquired by Motorsport Aftermarket Group.

E-CommerceAcquired

NicView

NICU webcam streaming system letting families remotely view hospitalized newborns. Acquired by Natus Medical.

HealthcareAcquired

Telemics

Sensor technology company for electronics and embedded systems. Acquired by TE Connectivity.

ElectronicsAcquired

SuperFanU

Mobile fan engagement platform offering rewards and incentivizing fan participation for athletics programs. Acquired by PrestoSports.

Software & TechAcquired

Aperture Credentialing

Healthcare credentialing and provider data management platform. Acquired by Verisys via Stone Point Capital.

HealthcareAcquired

Talaris Therapeutics

Biopharmaceutical company developing cell therapies to eliminate chronic immunosuppression for organ transplant recipients. Merged with Tourmaline Bio.

Life SciencesAcquired

BehaVR

VR-based digital therapeutics company using immersive virtual reality for behavioral healthcare. Merged with OxfordVR and Fern Health to form RealizedCare.

HealthcareAcquired

Pruvit

Exogenous ketone supplements and ketogenic drink mixes. Acquired by Herbalife.

Food & BeverageAcquired

Aptamera

Biotech company developing aptamer-based anticancer drugs with orphan drug status for pancreatic cancer. Acquired by Antisoma for $21.4M.

Life SciencesAcquired

Accent Intermedia

Gift card and prepaid card products and programs using web technology and fulfillment. Acquired by Next Group Holdings.

FinTechAcquired

Aperity

Data management and analytics company whose Beverage Data Exchange was the industry's first community-centric data solution for beverage supply chains. Acquired by Financial Information Technologies.

Data & AnalyticsAcquired

Modern Gigabyte

Creator of ModernBill automated billing system used by nearly 15,000 hosting resellers worldwide. Acquired by Parallels.

Software & TechAcquired

Narrowcast Partners

B2B media company publishing IT Business Edge and IT solution provider directories. Acquired by QuinStreet.

MediaAcquired

Dealer Car Search

Website and software solutions for independent automotive dealerships, serving over 6,000 pre-owned auto dealers. Acquired by LeadVenture.

Software & TechAcquired
Est. 2006

RentalHouses.com

Online rental property listings platform connecting renters with available houses and apartments. Acquired by RentPath.

Software & TechAcquired

Revon Systems

AI-enabled digital health platform for managing chronic health conditions and collecting real-world evidence for clinical trials. Acquired by ZYUS Life Sciences.

HealthcareAcquired
Est. 2013

Hosting.com

Managed hosting and data center services provider. Acquired by Ntirety.

Software & TechAcquired
Est. 1997

Generation Tux

Online suit and tuxedo rental company founded by Men's Wearhouse creator George Zimmer.

E-CommerceAcquired
Est. 2014Website

Street Moda

Online retailer selling designer footwear and apparel at 30-80% off retail.

E-CommerceAcquired
Est. 2005Website

Donna Sharp

Quilts, bedding sets, and home decor accessories in traditional, coastal, and seasonal styles. Acquired by American Heritage Textiles in 2017.

E-CommerceAcquired

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